Strategic issues and long-term trends are handled by:
A. Software system developers
B. Hardware system developers
C. Senior management
D. Middle management
E. System analysts

C. Senior management

Explanation:
Senior management is responsible for setting the strategic direction of an organization and addressing long-term trends. Their role includes making high-level decisions that impact the company’s overall goals, vision, and strategy, while middle management focuses more on operational and tactical issues.